I actually successfully updated to High Sierra (avoiding APFS) with all apps and plugins working so now I'm good with the Sonnet 10G USB card. But now I understand that a lot of these 10G cards are using the ASM controller & firmware which is why they aren't compatible with El Cap. Good to know that I could have changed to the 5G firmware to get it working if I had to.
Do you like the Sonnet card or do you think there are better offerings for the money? I eventually want to find a USB 3.1/eSATA (two ports each) combo card so I can ditch the E2 and free up a PCIe slot for something more useful.
You can't get much better than the CalDigit FASTA-6GU3 Plus for USB 3.1/eSATA. I like that it uses a 4 lane upstream PCIe switch, which allows getting (almost) full performance from a USB 3.1 gen 2 port when the card is in a PCIe 1.0 slot, or a PCIe 2.0 slot that does not support x2 link width. I don't think either of those problems exist in the MacPro4,1 or later. The PCIe switch is required by the card to connect the SATA controller. This is probably better than cards that use a USB to eSATA converter.
The Sonnet Allegro USB-C 4-Port PCIe Card is similar to the CalDigit FASTA-6GU3 Plus. It just replaces the SATA controller with another ASM1142.
For the best USB 3.1 gen 2 performance, I use a GC-TITAN RIDGE in my MacPro3,1. Consider that the ASM1142 uses PCIe 2.0 x2 which allows only 5*2*8/10 = 8 Gbps. The GC-TITAN RIDGE is PCIe 3.0 x4 and therefore the built-in USB controller won't be limited by PCIe 2.0 x2 so it can get closer to the 10 Gbps limit (I suppose you won't see the difference unless you do a lot of really long sequential reads). Also, it does Thunderbolt 3!
I am not considering price.
It's too bad that OWC doesn't make a SATA converter for the Accelsior blades of the E2 so you can reuse them with a standard SATA connector. You could place the card in a Thunderbolt PCIe expansion box but that gets expensive.
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