I don't think I'd put the CPU in a node, but certainly anything that goes on a PCI-E bus might take a pretty negligible speed hit on a node.
The only stuff I've seen is over GigE and you just send chunks like a You tube buffer. So it has it's purposes but better a video render farm than audio DAW. Your PCI bus on an Audio DAW would most likely be latency sensitive DSP module processors which are themselves an extended processor to limit latency on the host. Or even more sensitive DA/AD conversion. Not much else would be there.