i bought a pair on wednesday & have used them fairly extensively since then. i'm highly impressed!
i was coming from a few pairs of headphones:
1) a patched up pair of beats solo 2 wireless which i use during runs
2) bose qc35 for longer distance travel
3) a £30 pair of in ear headphones for use on public transport
4) apple's supplied earpods for music at my desk
i did previously own 1st gen airpods, which i used for the 3rd and 4th categories practically daily until they were stolen after about a year. i really liked them, but their lack of isolation & noise cancellation meant they could never replace my beats or qc35s for exercise & travel.
in the past few days, i've used the new airpods pro on a coach, on a plane, on a train, on the london tube, whilst running, and in the gym, and the noise cancellation and sound quality is so good that i see no reason to use either my beats or my qc35s from now on (except on particularly cold days when they double up as ear muffs!).
using the standard tips (which fit me well: i'm yet to even try out the other sizes!), i compared my pros and qc35s side by side on the coach and the plane, and for me, the noise cancellation was superior on the pros! i noticed they were more effective in blocking out sustained, higher pitched sounds from the cabin, and i didn't feel uncomfortable pressure in my ears (which i do sometimes experience with the qc35s).
transparency mode is really useful whilst at my desk or out running, and they stayed in comfortably whilst i ran to work this morning.
my only criticism is that the batteries cannot be replaced. given how much use i foresee me getting from these, i'll definitely be getting applecare to mitigate this.