Yes.
I'm using a 5.2 screen Android right now, HTC 10, which I thought was my absolute top end as far as phone size. But I'm about to pull the trigger on an XR, which really isn't that much larger than the HTC as far as the dimensions even though it's all screen.
But that absolutely WILL be my top end, I'll probably hang onto it until it disintegrates, because I understand that folks like me have been outvoted by folks who game and watch video on their phones (I don't, ever, although I have no criticism for folks who do, we all have the right to paddle our respective canoes in our own chosen ways) and phablets are the way of the future.
I'll adjust. I have tiny hands and I already use my HTC two-handed, I've test-driven an XR and I think after dithering about it I can handle it. (I'm also a klutz so the XR will as all my phones do go into a brick of a protective case with a TGSP; I could care three cacas about a phone's style and elegance or even its color, I plan to get black; the thing is a tool for me and even though I always get uh-oh insurance I want to avoid trouble if at all possible.)
I've also been rocking the leather belt pouch since I got my first smartphone, LOL! It's geeky but it works for me. Like I said, my phone is a tool and that's where I want that tool to reside when it's not in my hands.