I developed RSI in right wrist mousing. My experience: 1) Took a few days to learn to mouse left-handed. It comes pretty quick. 2) Magic Mouse lightly cradled at an angle roughly following the angle of the thumb (index finger is primary touch others rest on desktop). 3) Keep your hand aligned with forearm -- there is almost no angle in my wrist when mousing. 4) Get BetterTouchTool and program your mouse beyond what Apple provides. Hope this might work for you. Do not mess around with RSI -- fix it. I almost got to the point where physical damage might have occurred (stupidly stubborn). With the setup above I have spent many long hours without issues. YMMV of course. For me the key thing is having my hand/forearm aligned (virtually no wrist bend.) Never seen anyone else do this, so perhaps it is unicornish for me.In January, I started developing repetitive stress injury in my right hand and forearm that I assumed - correctly it turns out - was related to mouse usage. Being extremely right-handed, mousing with my left hand seemed ill advised, so I thought of getting a Magic (jeesh, do I hate that descriptor) Trackpad but balked when I saw it was still a Lightning device.
Having finally achieved "one cable to rule them all" status (well, except for the micro USB cable for powering my e-reader until I get a new one), I'm not about to go back and so opted instead for a small ambidextrous mouse that I've learned to use - clumsily but less and less so - with my left hand. Doubt I'll be opting for a MT now.
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