Don't think Microsoft can afford for it not to work, x86 isn't catching up to Apple in perf/watt even if they can tread water in raw performance terms, and current x86 chips are about at the limit of just pumping in more power.
But they are catching up. AMD on TSMC N5 is better. Apple iterating SoC at a pace 18+ months won't necessarily race forward faster than AMD/Intel are moving at 4-6 years from now. Intel is throwing more power consumption at their laptop Gen 12 and 13 SoCs, but AMD isn't (because have access to better fab nodes and are consistently iterating. Mobile hasn't been a primary focus for AMD but as they gotten more financially stable they are starting to turn the ship on that battlefront. ). On desktop CPU and GPU Intel/AMD are throwing out the possible Perf/Watt overall gains out to overclock to higher benchmark metrics. But when set not to 'over reach' they are making progress. There is no good evidence that they are fundamentally 'stuck' on Perf/Watt on some technological basis on any possible SoC design.
AMD/Intel are not going to get to "close enough" perf/watt parity in 1-2 years, but 3-6 years out is not a sure thing. Nor does x86_64 need to carry around all of the 1980's and 1990's baggage to run 32 bit OS in 3-6 years. In 2025 when Windows 10 dies, AMD/Intel can let go of some substantive 'boat anchor' features for mainstream SoCs.
Healthy and real competition between AMD and Intel will keep them moving forward on x86_64. With some outside competitive pressure it likely will get easier to throw some of the boat anchor, old stuff into non mainstream SoCs ( and clean up the mainstream SoCS. )
And if Apple keeps sticking to their "only Apple GPU drivers only" path for next 5-6 years they aren't going to capture broad swathes of PC market they don't have now either.
I still think x86 will be all but gone from consumer computing by the end of this decade, Apple are going to keep pushing ahead and Microsoft and Google are stepping into chip development in their own right to keep up.
Probably rolls well into at least the next decade as the major player. Windows 10 doesn't even go away until 2025. Apple will dump macOS on Intel by end of the decade. But that is only going to create some refugees onto Windows on x86_64. Laptops have taken large share away from desktops, but the smaller, more 'die hard', remnants of desktop are going to be harder to move.
Arm will proliferate into a higher volume of non-Windows devices ( more phones , tablets , heatsets , etc) , but Windows + any arch SoC has problems there anyway. x86 isn't really the major problematical issue there.
In the Windows space , as long as the top vendors (i.e., at the moment HP , Dell , Lenovo) are "sell everything to everybody" vendors if any one of the three says " we are quitting x86_64 entirely" then the other two will say "buy from me we still sell everything for everybody". Either you have to get all of them to quit all at once at the same time or you have a transition problem. Microsoft cannot unilaterally make that call. Have a chorus of system vendors with completing goals to manage.
All of that will slow the decline. There will be substantive share loss , but relatively rapid implosion? Probably not. There is no "slam dunk" easy "whole market" Windows win here for Qualcomm , or any other Arm vendor.