Yes. Big time. I had to turn off iCloud, almost all notifications, reminders, push and fetch mail every 30 minutes with 0 apps running just to get 5% degrade an hour.
UPDATE: after fine tuning the settings, I have lost 7% battery in 2 1/2 hours. Not bad.
Reminders off, reminder notification off.
Push off. Find myiphone on.
These notifications are on: weather, mail, Facebook, Tweetings, ap mobile, messages, calendar.
Fetch mail ever 1/2 hour.
Location services are with: maps, Facebook, camera, weather and Tweetings.
iCloud OFF!
I will slowly be turning stuff on, day by day and see how it goes. But for now thats what I'm running. Oh, and killing apps when I close them. None left running.