I'm with barmann here. You need to figure out which way you want to go (what you can do under Disk Utility vs. hardware RAID - do not use a software solution for RAID 5, as you will get burnt).Yeah, it does seem rather expensive. What are your thoughts on its sister product, which has RAID 5 built in and can connect via FireWire 800? I wasn't planning on using a RAID scheme, but RAID 5 on my backup would be that much more secure, would it not?
The MP is capable of 0/1/10 and JBOD (spanning), and when combined with a PM enclosure and an eSATA card, is a very cost effective solution. The other way (what you're looking at anyway), is to go RAID 5, which you need a proper hardware solution (at least the Oxford 936QES is a RAID on a Chip <RoC>). It's not that robust, nor fast, but it will do the job. I just hope you realize that you will lose disk space due to the parity data [(n - 1) * capacity of a single disk in the set]. So for 4x disks, the usable capacity will be 3x disks.
It's up to you, as in barmann's case, it needs to be able to connect to multiple systems (where USB or FW have an advantage - can connect to laptops and iMacs).
As per the unit you linked here, it's also too expensive. It's the same chip that's used in OWC's Qx2, which can be had for noticably less money ($300USD), and still matches the MP well in terms of industrial design (appearance). So unless that flat unit is so attractive to you in terms of where to put the storage unit, I'd stay away from it. The format is just too expensive for what you get.
This is just an expensive Port Multiplier enclosure (it will work with the card you've linked as it does support PM chips).
But again, you can get the same solution for less money (Sans Digital TR8MP, which comes with the card).