My 5D has been trouble-free for many years. I've had to replace two disks over that time (one as a precaution due to the error count and one that eventually hard-failed), but I run dual-disk redundancy (5x4TB with two disks as backup) so never worried about data loss. I have recently pulled the front cover off my Drobo so it can breathe better and keep it well off the desk.
I have heard a fair bit of complaints about how unreliable they are, but then it is the ones who are not having issues who don't ever say anything.
I did have a Synology before my Drobo, but found it super-slow and it ate HDDs so I took a chance on the Drobo.
All the above being said, I would not buy a Drobo today. I don't like that it uses it's own proprietary data format so if you lose the box, you have to use another box. I do keep two full backups of the Drobo, so never worried about data loss, but in the future (or if my unit ever fails), I plan to get an OWC four-bay and run Raid 1+0.