I have the Dell UE2723QE and am using it right now with my 2018 Mini.
The OS is Mojave (still) and I also have BetterDisplay running (free version).
I DO NOT have speakers connected to the display.
For sound, I use headphones connected directly to the Mini.
If I bring up the BetterDisplay pane on the menu bar, I see this:
View attachment 2483837
You can see an entry there for "Volume (DDC)".
So it looks like BetterDisplay can control -something-.
Not sure if that would be speakers "internal" on the display or external speakers connected "through" the display.