I updated my MP 4,1->5,1 to High Sierra today. Firmware update went OK, as did the software install. The only oddity I encountered came when installing the nVidia web drivers - after clicking install, but before the computer restarted, a dialogue popped up stating that a problem was encountered during installation and asking if I wanted to continue or cancel.
Strange, I too updated my MP4,1-5,1 to High Sierra and then installed the nVidia web driver which recognised my stock GTX960 without any problem. Before installing the web driver I was running with my old GT120 and had a couple of crashes that seemed to be related to Apple stock driver. Maybe the GT120 is no longer properly supported?