It's basically as difficult as the hard drive was in the 2012. Maybe a bit easier since you had to take out the power supply on the 2012s right (it's been ages since I did it). The only "risky" thing is pulling it apart too fast and forgetting to unplug one of the smaller cables (antenna, fan, front LED). I'd say a 4/10.
I've generally tried sticking to Crucial, but I dont see any reason why another brand wouldn't work. These shipped with Micron modules (manufactures Crucial), but they used to use Hynix. I wouldn't be surprised if a couple of brands didn't work for some odd reason though. I'm sure that info will surface since a lot of people are picking up Patriot Viper, G.Skill Ripjaws, and Corsair Vengence sticks since they're a bit cheaper than these Crucial Ballistix. I figured I'd spring a bit more for the ever so slightly faster CL timings (even though I won't even notice)