working on my Mac Pro 2009 2.66 GHz 8-core, flashed to 5,1, some time ago to try and get 32GB of 1333 MHz RAM to work but didn't. Thought I did it for nothing.
You may already know this, but...
Remember that you need to flash the PRAM (Command-Option-P-R until you hear a second chime at startup) to get the system to recognize the 1333MHz RAM, and you'll need a CPU (Westmere) that will recognize it as well. If you were still using the 2.66GHz 8-core CPU arrangement, or if you didn't zap the PRAM, your RAM would still run at 1066MHz.