*****I'm having this same issue with the MacPro with the D300. Ever since I got it, it's had totally random freezes, sometimes beachball, music will continue playing, but no response from the UI other than the mouse still moves. If I check the logs it says that message about the GPU and "5 continuous seconds of unreadiness." The freezes are very hard to recreate as they seem to occur randomly. Sometimes playing computer games, or sometimes just browsing the internet, or moving folders around in the finder. There's no pattern to it.
Unplugging the monitor does clear up the freeze, but the system is too slow after that and needs a restart each time.
I took it to the Apple store where they replaced both graphics cards, and it worked well for about a month. Then, it started freezing up again, about 2x per day. Took it in again, where they did a "deep restore" to factory default. Took it home, and it's doing it again. Something is seriously wrong with it!
Not sure what to do at this point, if some are reporting that 4 new macs later they are still having the issue. Is it an issue with certain types of monitors? Is there some other type of monitor where people are not having issues? If anyone is not having this problem with your mac, what is your monitor and setup? Has anyone had luck solving this issue yet? My mac has been doing this for a year!
It might not be of any help but here is my experience.
My MP has D500 GPUs and I still use a 2007 Samsung 24" HD monitor connected by a Display Port (Thunderbolt identical) to a DVI adapter cable.
I have this computer since April 2014 and never noticed this freezing which causes problems to you and to many other owners of this MP model.
The assumption mentioned in a previous post in this thread that according to Apple only D500/700 GPUs are affected while D300 are not...is therefore wrong.
You have the problem in D300...while I haven't it although in my mac they are D500 (but not manufactured in the period mentioned by Apple as critical but much before).
I don't think that my rather old display might have anything to do with the problem affecting you. I just mentioned it because you asked about monitors.
Ed