At this moment, T2 chips sometimes blocking certain USB driver from loading in OS. When checking logs, it would show T2 interferes error log on my 2018 15 inch MBP . On older Mac Pro which doesn’t have T2 chips, they loaded just fine. So T2 was real culprit in my case. Those happened on Wacom USB driver, Logitech and USB Overdrive. T2 is also not playing nice with ESXi unless with some workarounds.
No problems with the Wacom and Logitech USB drivers on a 2019 T2 Mac Pro here.
T2 doesn't do anything to block Kexts. It sounds like a different issue.