OK, I did some testing in my Sequoia install which is an APFS volume on the same drive as the main Monterey install. I installed my Epson software drivers for my ET 2800 series, and my Perfection V600 scanner, and everything seems to work. The thing that really made me question if the system was working correctly, or not in regards to permissions is:
Many of Epson installer packages, behave differently under Sequoia than Monterey, for example under Monterey, it just goes through the standard screens of where it will be installed, agree, enter the password for admin, and done. Under Sequoia, it adds the screen saying who do you want it installed for, and for all users is the default, and since some of the installers took slightly longer than on Monterey, I wasn't sure if this was a difference in the version of macOS, or if OCLP was doing something to the system where it wouldn't be reliable. Everything works, so I'm guessing it's mainly a difference in the versions of macOS, but that's why I specifically asked how can I know what's causing the difference in expected behavior, since I don't have newer mac to test with right now. This is also why I asked How I can get as close as possible to a standard setup with OCLP by disabling SIP, since it's not possible to fully enabled it with a patched OS.
As far as printing, I was able to do my test patterns through Preview as normal.
By the way, the GPU related stuff I've figured out how to work with, so it's not as much of a limitation. So, now it's permissions and overall functionality of newer versions of macOS I'm still trying to sort out.
Also after using Sequoia for a while as a daily OS, there really isn't anything it has that I need on a daily basis over Monterey. The two main things I've seen in my case, is simply being able to update apps to the latest version. Even with that though, at this time, the differences are usually very minor, and not worth relying on an unsupported configuration for. At least not without a supported install to go back to.