I've really just got a big kick out Sequoia performance on this iMac, 17,1. After doing some reading on Reddit, I have turned off a few things in the OS, I don't use, and 1 thing I didn't realize made a difference, and things are almost instant now, and login is a lot faster too on reboot.
What I disabled was:
Siri (i don't use Siri on the Mac)
Animate opening Applications (didn't think this would help, but apps open faster)
Reduce Motion (even removing the little animations, makes things run faster, I was so used to it, that I was surprised when I saw the difference.)
Use iPhone Widgets (up there with I don't use desktop widgets, and I just use the phone widgets on the phone.)
Show Widgets on Desktop and Stage Manager (I don't use desktop widgets), I keep them in the notification center where they've always been prior to Sonoma.
I tried Reduce transparency, but I didn't make a difference for me in performance, and it makes the dock look tacky. So, I left that on.
Now, I'm going to investigate Telemetry. Not because I have issues sending data that can help improve things, but to see if it makes a difference with performance.
Here is the Reddit link I've been reading, and got these suggestions from: