You cannot lose a boot drive or any drive because of OC. You can cause a mac pro to become a brick if you attempt to go beyond the steps outlined in the OP's first post ie. Spoof/manipulate SMBIOS, NRAM etc without understanding the advanced options of OC or having a matt card.This is to acknowledge that I have just lost my bootdrive after applying the Opencore. I've removed it from EFI partition and reset the NVRAM. All data in the drive is still accessible thru another boot drive mounted externally, so I could still rescue all data in it.
I understand this thing is under experimental development and I don't blame anyone who contributes to this. Just want to say this thing is unsafe for now under dual boot configuration. Some boot parameters could be fatally damaged during booting A B drive configuration thru the NVRAM. Even resetting the NVRAM wouldn't help. Make sure you have a backup copy before proceeding anything on this thing.
Keep up good work.
Edit: I'm dual booting Catalina and Windows 10 EFI.. No issues.