I have the mouse connected to the keyboard and only the keyboard connected to the USB port. Second issue is freeze of certain Apps with some devices. For instance I have a USB Bluetooth, which if connected freezes ioregistry explorer and some other Apps. My iPad sometimes freezes apps when I connect it to a USB 3 PCIE card. I might have fixed that issue with the USB map kext.OK. I've just verified this with an Apple wired mouse connected directly (rather than connected to the Apple wired keyboard).
This patch provides a USB1.1 support. We might want to take a look at it:
GitHub - SuperBox64/bigmac: Big Mac, macOS 11 Big Sur and macOS Monterey disk installer and back up tool for Intel based Macs
Big Mac, macOS 11 Big Sur and macOS Monterey disk installer and back up tool for Intel based Macs - SuperBox64/bigmac