I know that in system profiler I see that TRIM SUPPORT: YES is shown, however, does the drive automatically process TRIM functions or is using a program such as Disk Sensei from @Cindori for the auto trim or manual trim still required and/or beneficial?
No. Trim support is just that. When Trim is enabled either by a third party utility (Trim Enabler), native in the OS (Apple SSDs), or by a terminal command (OS 10.10.4) the result to the SSD is the same. The Trim routine is active.
Lou