I don't understand why people have 50+ tabs open at once....Maybe I am just old but what is the problem with bookmarking something you might want later and opening it when you ACTUALLY need it rather than leaving it open along with the other 49 things you aren't currently looking at....
Because many people's work requires multiple streams of activity, and you lose time reopening the page and having to find the part you were looking at. It's the equivalent of closing a physical book and putting it back on the shelf. You have to remember the name (or URL, tags) of the bookmark, find it in your bookmarks hierarchy (which may have many thousands of items), open the page, and then locate the exact section you were looking at. If the bookmark doesn't have the URL anchor (# symbol that defines the section of a single page), then you have to hunt on what could be a long web-page - certainly far longer than any physical book page.
You also have to fill up your bookmarks lists with "temporary bookmarks" for stuff that you may only really need for a day or two but don't want to commit to a permanent bookmark set. (I am now using "Reading List" more for this purpose).
I don't know about everyone else, but my work involves a lot of reading and writing (Cloud software and infrastructure architecture), and many of the productivity tools are web-based (management consoles, wikis, workflow, task boards, document repositories). This all requires a lot of open tabs. I typically divide these into multiple windows (like sections of the "library"):
1) Infrastructure management consoles (typically 6-12 tabs of AWS console pages showing dashboards, metrics, logs, service status)
2) Project Documentation: mostly wiki pages that I am reading or writing - generally refer to at least 6 pages at once for any given set of tasks
3) Task management: things like Jira boards, Asana, GitHub repositories & other workflow tools
4) Research documents: web-pages that are helping me solve my tasks - could be dozens here if I need to read widely on a topic.
5) Personal: personal e-mail, news, & macrumors
If I had to close all those down every time I stopped using them for an hour or two, I would spend a huge amount of time re-opening them and getting back to where I was.
That said, I am now adopting a more strict policy of either closing tabs that I know won't refer to during the same day, or using the Safari "reading list". This does tend to reduce my memory usage and by extension swap usage and disk writes.