Separate Thunderbolt channels - you mean separate Thunderbolt buses?Two 4TB NVMEs in 40GB/s Thunderbolt 3/4 enclosures on Mac Mini 2018 - 4GBs speed!
I've used two (2) Acasis 40Gbps NVMe SSD enclosures, with two (2) Nextorage Japan 4TB NVMe M.2 2280 PCIe Gen 4 (similar performance and quality as Samsung 990 PRO 4TB, however for much less - I've also got them on sale in Nov/2023 for about $180 a piece).
I've used this with my Mac Mini 2018 connecting it into two separate Thunderbolt channels, and I've setup software RAID 0 (data stripping across both drives).
The total usable capacity I got with the two drives is 8TB of storage space. Results are 4gb/s RW transfer speeds. Compared to 2.5gb/s for the built-in Apple stock drive, I'm super satisfied with the result.
Mac mini 2018 has two discrete Thunderbolt controllers (buses) with two ports each. Each controller is limited by PCIe gen 3 x4 upstream to the CPU (≈3500 MB/s). I would expect ≈2700 MB/s (up to ≈2800 MB/s) for a single drive, slightly more than that for two drives connected to two Thunderbolt ports of the same Thunderbolt bus, and ≈4000 MB/s (up to ≈4500 MB/s) for two drives connected to separate Thunderbolt buses like in your setup.
MacBook Pro with Intel IceLake CPU has integrated Thunderbolt controllers which means they are not limited by PCIe gen 3 x4 upstream to the CPU. Each side of the MacBook Pro is a separate Thunderbolt bus but you can get ≈4500 MB/s from a single Thunderbolt bus. The max is ≈4700 MB/s from using three or four ports.
Apple Silicon has a separate integrated Thunderbolt controller for each Thunderbolt port.