Kind of a mess, but temporary...
I use my nMP for a variety of media creation and management, including Final Cut Pro 10.1, Handbrake, Compressor, Adobe CS6 (mostly Illustrator, Bridge and inDesign, some Dreamweaver) , VueScan, etc.
Part of the mess is that I have a large number of USB peripherals that I attach via a 24 port Manhattan powered USB hub. Also there is a second computer, a MacMini that I use for stuff like tax returns, etc. I am thinking of transferring all my nonessential stuff requiring access to the boot drive (iPhoto) to the MacMini since I have found that it uses a horrifying amount of the SSD in the nMP. Whatever you do, if you get one of these, get the biggest boot drive you can afford. I just had to have mine in 2013 so I opted for the stock configuration with 250GB.
Attached to the nMP are a Wacom Intuos 4, Nikon Coolscan V film/slide digitizer, Panasonic AG-1980 VHS deck (via a Firewire digitizer and FW-Thunderbolt adapter), a Canon GL-2 similarly connected for ingesting DVD, an Epson V600 flatbed scanner and my main video storage, a Promise Pegasus 2 R4 configured in RAID 5. Also a couple of smaller external HDDs for specific backups and SuperDuper for the boot drive and various Nikon cameras. I am compulsive about backup and am thinking about getting a second 12TB Pegasus to configure as RAID 1 to back up the R4. The idea of redigitizing all the original and converted media on the R4 is simply unimaginable. Cloud storage is not an option as I live in a very rural area and all we have is 1.3 mbps DSL in our area.
I am looking at this forum and others to get a better idea of how to set this whole business up more efficiently. Interestingly, the ONLY new wire associated with the nMP is the Thunderbolt cable to the Pegasus. I had all the others on the old setup.
In the picture you can see the keyboards for the MacMini and the Das Keyboard (nice to use but sometimes slow to connect) for the nMP and the old Apple mouse and the Magic Mouse and Touchpad for the nMP. Some of the wires are for the television (not in picture). The Wacom is under the Apple KB. The Manhattan hub is next to the Pegasus. Also Lizzy Borden, a gift from my daughter. She's fascinated by this century old mystery!
The absolutely awesome performance of the nMP on Handbrake, FCPX and Compressor made the purchase absolutely worthwhile. What used to take hours now takes minutes. If you are doing anything with video, get a Mac Pro 6,1!!