I just got my 5870 installed in my 2008 Mac Pro earlier today. Here's what I have so far:
The card is installed along with a HD 2600 XT which is in slot 2. I drive four displays.
1) 30" Cinema on DVI of 5870
2) 15" Dell on MDP > VGA of 5870
3 & 4) 15" Dell on DVI > VGA of 2600
I am regularly having to unplug the MDP display and back in again after a reboot or cold boot, as it isn't detected otherwise. If I go to Detect Displays it lights up though.
Oddly, when it's blanked, my cursor still "goes to it" between the 30" and the next display to its right.
This happens in Windows too. Here's my big issue though, which I also had in my 2.4 GHz 17" MacBook Pro (which I no longer own).
The 30" has flashing intermittent blue lines on it only on Windows, and only when the MDP display is plugged in.
On my MBP the blue lines (which look exactly the same) were on the 30" all the time.
30" (DVI) + MDP = Blue Lines
30" by itself = No blue lines.
Two 15" displays, one on DVI > VGA and the other on MDP > VGA, no blue lines.
So it's only when the dual link DVI is being used it seems, and only when the MDP is being used along with it. And it's only on the Windows side, which is nice. On my MBP it was in Mac and Windows.