I'm starting to think that the HighPoint 7120 might be the best adapter for the classic Mac Pro.
The 7120 has the same PLX situation as the 7101, but instead of M.2 slots, it has U.2 ports. Because of this, the adapter is a half hight card, as well as shorter, so you won't suffocate you video card when placing it in front.
Because you don't need to cool any M.2 drives on the card, it has passive cooling with a large heatsink, taking care of extra noise issues.
You would be able to run U.2 cables up to your drive sleds and then either a) purchase U.2 drives to use (I'm looking at Intel Optane, but I am wondering what other options there are) or b) you can get a 30$ U.2 to M.2 adapter the shape and size of a 2.5" drive.
You could mount these drives or adapters up with your sleds with the right adapters. U.2. also in theory is backwards compatiable with the SATA ports if the Highpoint ever died, and supposedly supports hot-swap, although that is most likely OS dependant.
Did I mention they (7101 & 7120) cost the same?
I wonder what U.2 drive options are out there, and how they compare in cost and performance to the M.2 drives we are looking at, and if the cMP would boot correctly from them, although I believe it should, as it's just PCIe attached NVMe storage.