Cable can be problematic when I do the 3 Titan X mod. When I first got the xbox 360 175W power supply I did not cut the wire and solder the wire to the 8+6 pin arrangement. Because it has the socket, and it's not ordinary socket, so I kind of just make 6 spiral copper wire inserted into the 3 12v and 3 GND pin slot of the socket to the pcie connectors and test it. It's not stable in that way. It would shot down and some times black screen. So the hardness do affect the power supply here. I'd say Pascal is a little bit more sensitive (hard to describe it) to little voltage change. You can tell some times the shot off at event not even begin any heavy load. With the theory in mind. I than cut the wire solder it to connectors (don't use the socket to test any more). It is resolved with soldering. Never shot off again.
Back to your physical issue, let's say your cable is fine but you have to understand another discussion here is that Mac Pro 5.1 although has enough 250W to the 1080 Ti from the 980W PSU, yes from the two 6pin as well, but individual 6pin + another individual 6pin is in doubt to not to trigger shot off on the board which is individually sensed. To avoid that, pixlas mod is one, or like me solder a pair of 12V +GND on the Main PSU. For you, only one 1080TI should be no issue unless something unusual exists, but you may take a look at the description of the EVGA power link (check some photo from the thread for understanding).
see #4
https://forums.macrumors.com/threads/ultimate-mac-pro-5-1-mod-for-triple-titan-x.2043646/
This device will internally balance/bridge both 6 pin together into your 1080 Ti. This is different from if you just plug 6>8, and 6>6 into your card. When I bought it was $9.99. now $29
. But if you can go to local Fry's maybe you can make quick purchase and test it. I think this can be your first thing to try before you do the Pixlas mode, if you think cable is probably the reason. And let us know.