For liquid cooling, yes you would need to ditch the thermal core or whatever its called. But still would be possible bringing air through that vertical shape, and dissipating the heat with single fan.Is there enough space available for these?
Perhaps a redesign is required?
About the PSU I think that both 1300W and 300W use the same amount of space . Of course here(nMP 6.1) is barebone electronic board with coils. That would not require redesigning the case.
Overall you would not need to change the shape, height and width of the 6.1 with those updates.