I do but after a week or two of using the N5 it feels extremely weird to use an iPhone so I guess I'm used to it?
I don't think it helps being left handed either. If I was holding the phone in my right hand I could comfortably wake it with my thumb then use without readjusting.
I have average sized hands and I couldn't reach the wake button with my right thumb and then use the phone without shifting my hand down.