This is my work setup. Three screens connected to my 11" Macbook Air via a couple USB graphics adapters and the thunderbolt port. It all sits on a height-adjustable desk. Very nice to work on. Headphones are Sennheiser HD 280 Pro.
The two large screens are also connected to a high-end PC for CAD work. The black mouse is for the PC. The magic mouse is for the laptop. Monitors are 24" 1080p Dells with another Dell at 1280x1024. It all works out nicely. I have a template to chop up pictures for my four screens that adjusts for different DPI, bezels, and space between monitors.
Is that 11 inch Air powerful enough to power all those pixels??