Following up with another data point for the thread. I updated my single to double and it is, like all affected, a 4,1 to 5,1.
Same audio stutter / sound crackle issue. Most noticeable for me with iTunes and Spotify as well as editing apps such as FinalCut. On YouTube the effect is milder.
Stutter is present regardless of I/O port. What's interesting is that the stutter sometimes is present, and sometimes it is not. The only thing that makes a difference for me is completely powering off, and starting up again. Sometimes unplugging the power cable for a couple minutes, and then restarting seems to help but only temporarily.
Update: the only thing that somewhat mitigates the problem is resetting the NVRAM. I just did that 3 times, and then the SMC (unplugging for 15 secs, then waiting 5 secs before starting up again) and the stutter pretty much went away.
Usually Youtube is hit or miss, but when the problem is present opening Spotify triggers it as well as iTunes. I tried both of those after this refresh, and after a 5ish minute song I started to hear a slight stutter. I wonder if it builds up over time whatever the issue is, and it gets cleared / refreshed once we do NVRAM / SMC reset. Even if we don't have a fix, I'm really curious to understand how it is that such a powerful machine can come to struggle with something as simple as audio.
Specs:
Mojave 10.14.6 on PCIe NVMe
[2x QuadCore X5570 2.93GHz]
64GB RAM // [Flashed & shows boot] Vega 56 8GB (w/2 displays via 1xHDMI 1xDP)
It seems that up to date, the only fix is to switch up processors and now I'm reading up to find out what is a good recommendation for this setup. I saw the compatibility list, but I welcome if anyone has a recommendation for a change of processors to get rid of this audio problem, while retaining or improving performance, or even longevity. I don't have to buy the top of the top unless necessary, since those consume more power overall right?
Thanks for the time!