bitrate has no impact - I´ve checked that before...
Doesn´t make ME feel that. You don't need much processing to get an audio stream working. I've build audio workstations since 1996 and issues like that I've never had related to the processor. Most of the time something like that was related to bad IRQ-handling or bad drivers.
Maybe here is a key: 10.14.4: Apple „Improves the reliability of USB audio devices when used with MacBook Air, MacBook Pro and Mac mini models introduced in 2018”. And something got lost...
I didn't say it well. Correct, there is nothing wrong at all with the physical processors themselves. They were doing great things last week on Mojave 10.14.3. Some change to a driver (or other software change) was made rendering them unstable for midi audio production on 10.14.4. The solution, in the end, may be to swap out the processors if Apple deems the 5500s to be deprecated. However, I'm assuming (actually, hoping) that something got lost, and that they will fix it in time.