After walking around playing Pokemon Go for a couple of hours, it seems like the Color Brick handles smudges and fingerprints pretty well, much better than the iPhone 12 version. I think there’s just enough of a gap between the screen protector and case to not get pushed up too. I really really like the smoothness of the case, but that also makes it not so grippy. The nubs on the side do help though.
Between how nice the case feels and looks to me, combined with having comfortable cutouts for my pinky, I think I might stick with this for the long haul.