I'm also joining the RX 6600 XT in a vintage Mac Pro crowd:
View attachment 2144548
View attachment 2144549
Sapphire Radeon RX6600 XT Nitro.
I was able to get the ROM out of it, use the tools provided here then re-flash it. It works fine on my 5,1 and it is powered by the same mini 6-pin to 8-pin cable as the RX580. The RX6600XT seems to run a lot quieter and cooler than the RX580. Thanks
@Syncretic for your instructions and work.
I used an eGPU enclosure to connect it to the 7,1.
EDIT: I had a problem after doing this and removing the RX 6600 XT from the 7,1 in that Windows would not start properly - I'd hear it boot and the intro sound but black screen on a USB-C connected screen and the LG 5K on Thunderbolt.
This was related to the Bootcamp display drivers somehow getting messed up - the solution was to connect a screen to the W6800X MPX Module with the HDMI cable and then the windows would appear normally. Re-install the Bootcamp display drivers and everything runs normally.