Have you every used an Android tablet with a cursor? it operates in the exact same way as pegging icons with your finger, but you click with your cursor instead. I repeat: Absolutely nothing in the OS or Apps user flow changes. Just clicking instead of tapping.
I have been doing that with my Galaxy Tab S4, and it works wonders toward full laptop replacement!
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The question becomes WHY would you do this. Look at the picture you posted with your byzantine, awkward, antiquated setup that is hamstrung by limited mobile software and applications, an oldschool mouse, a screen that is a stretch to reach with a ridiculous stand... And then look at this... which is what you're actually trying to achieve but in a very ugly way.