It's like arguing about whether apps will require the use of the also *optional* Apple Pencil to be used effectively. I really don't see what the concern is here. If the app works with a pencil, it will work with a mouse or trackpad for that matter.
It's similar, yes, but I don't think we can learn much from the Apple Pencil in this regard. There aren't three decades of historical pencil-centric applications and users putting pressure on the app ecosystem the same way there are with mouse support. The Pencil's strengths and features don't overlap nearly as much with touch input as a mouse does. It's not the same dynamic at all.
Plus, we can already point to several apps which are basically useless without an Apple Pencil. I doubt any people are using Procreate with just their index finger, for example. The Procreate app has many touch targets which are too small to easily use with a finger, because they just assume that users are using the more precise Apple Pencil. So, while it technically works without the Pencil, it's a rough experience if you don't have one. This is precisely the sort of corrosive decline in user experience that some people fear might arise from an officially supported mouse input for a much broader range of application classes.
With Procreate it's not really a problem because the Venn diagram of people who want to use Procreate and people who have an Apple Pencil is basically a solid circle. Is that true for a spreadsheet? Not at all.
With the Pencil the challenge seems limited to just the narrow slice of apps where the Pencil adds significant capabilities (drafting, artistic, etc). But with a mouse the risk isn't as limited and could potentially impact all sorts of apps across the whole spectrum of app categories.
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