I've been seeing almost identical battery life on my 6s with very similar settings to yours.
For me, this has been the case with all versions of iOS 10, starting with a fresh copy of the GM, and now trying this new beta. Can't seem to get more than 3-4 hours of usage in a day. Some of the iOS 9 betas were like this for me as well, but 9.3.5 was getting me on average around 6-7 hours of usage, and sometimes to 8.
I just find it extremely ironic that the 7 with iOS 10 brings an additional two hours of battery life...and as soon as I upgraded to iOS 10GM, my phone lost two hours of battery. Went back to iOS 9 just to be sure and was able to pull 7 hours today with the same settings.
Bizarre.
[doublepost=1474678858][/doublepost]As for changes:
While on a call, haptic feedback is extremely soft. I actually prefer this level, and wish it could be adjusted! I'd never noticed this before, so if it's not new, then my apologies.
Also, looks like the 'headphones only' option is working now for announce calls. Previously, this was only working for myself and others if the ringer switch was up.