Considering that standby time has worsened on iPhones since iOS 12, this is very likely. Updates have nothing to do with this aspect, either: my iPhone Xʀ on iOS 12 is significantly worse on standby than my iPhone 6s on iOS 10. Sadly, there’s a significant screen-on time difference now if you go 100-50% in one day or if you need two days to get to 50%. Perhaps today it sounds a little odd, but back when iOS 9 was the latest, the iPhone 6s wouldn’t differ too much.I actually think the youtubers getting 12h screen time do so in a row. Carrying your iPhone around all day, switching cell towers, the screen powering on in daylight going to max brightness, all that stuff uses way more battery than we think.
If you one of those "youtuber tests" in your home, the iPhone sitting on a desk, on wifi, you will also get 12 hours. That's just not a realistic use case.
You don’t even need cellular and notifications! The phone sitting on Wi-Fi with good signal is already far worse. This started on iOS 12 and was never fixed.