Perhaps
@JohnD could let us know if his Mini PCie slot is populated.
Here's my 11.4b1 report so far. I've been running 11.4b1 the past couple days, nonstop, testing whatever I can. I'm using a spare 2010 Mac Pro with dual X5677's, 48GB RAM, MVC-flashed GTX780, original WiFi/BT, and an LSI eSAS HBA in PCIe slot 3 that's not connected to anything, and drivers don't load in Big Sur anyway.
I have a SATA SSD in sled bay 1, with Martin Lo's OpenCore 0.6.8 package, and a Mojave install. I have a SATA HDD in sled bay 4, which was a CCC clone of my primary machine's 11.2.3 system, upgraded with every 11.3 beta, and is now running 11.4b1. I have a SATA SSD on a PCIe card in PCIe slot 4, which is now a clean install of 11.2.3, upgraded to 11.4b1. Finally, I have 2x 3TB HDD's in a RAID-1 mirror for all testing data, shared between OS's.
I booted 11.4b1 and ran about 14 hours of file copies to/from my FW800 RAID. I've not had any kernel panics or unexpected behavior once booted. I previously copied several TB's of data between my PCIe SATA SSD and the RAID in one of the later 11.3 beta's, also without issue.
Now for the boot reports... I rebooted 29 times from my SATA HDD in sled bay 4 - 26 successful, 3 prohibited symbols. I rebooted 23 times from the SATA SSD on PCIe card - 13 successful, 10 stalls/hangs that led to prohibited symbols.