You know that it is caused mostly by Chrome, right? i have two Mac Pro's 6,1 (at home and at work) and they have exactly the same problem. if you quit Chrome -this flickering- diasappears instantly. Same on my both computers.
At office i have D300 on Mojave 10.14.6, at home i have D700 on Catalina 10.15.5 Beta (19F72f) (both connected to Dell U2718Q 4K screen). On Mojave is really mild and it apears most as some horizontal lines on right side of the screen. On Catalina, it is going crazy, totally unacceptable. Disabling/enabling hardware acceleration in Chrome, it doesnt help!!! Firefox and Safari, they are safe and they dont cause this flickering.
Interesting point as i use Chrome.
I just launched my machine (single 4K display) without opening Chrome and the problem still exhibits.
I wish it was that simple!