I have Beta 6 running on an OWC Pcie SSD card, triple booting with Mojave and Catalina (both of those on an internal SSD) on a 2015 Mac Pro 5,2. When you say OC6 are you saying that your are trying to install using Open Core? I am using Micropatcher to do the install. i have three 2010/2012 Mac Pro 5,2 machines and have now been succcessful installing on all of them, one with a completely new install, one with an install over a previous version of Catalina and one with an install over a previous version of Big Sur Beta 5. At one point I thought that the PCIe card was gumming things up, but I have experimented enough to find that, in my case with the OWC card, it is not a problem.