I understand your question just well enough to know that it doesn't belong in the OCLP Security thread. Other than that, I'm not sure what you're asking. I'll take a guess without fully understanding and hope that this helps.
In my opinion, you should always try using OCLP to build/install your Open Core EFI with unchecked "Disable Library Validation" and "Disable AMFI" (uncheck the boxes in the OCLP GUI). You should not need to manual inject any amfi-related boot-args in NVRAM.
If that doesn't answer your question, I apologize for not understanding the question.
EDIT: Note that you will need to "Build and Install Open Core" any time you manually change/override the "Security" settings in the OCLP GUI (different from the security discussed in the "OCLP Security" thread). You should be able to experiment with different Library Validation and AMFI settings simply by: 1) check/uncheck the boxes in the OCLP GUI, 2) Build and Install Open Core and 3) reboot. You should never need to manually inject boot-args or manually modify the Open Core config.plist unless that's your preference (I do manually modify config.plist for experiments, so I'm fully supportive of this if you want to and are able to). I'd recommend doing your OC EFI experimentation with a bootable, GUID partitioned USB thumb drive. Keep your SSD EFI untouched so you have a reliable boot drive.
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EDIT2:
@RK78 Just out of curiosity, are you trying to use OCLP on a Mac where you previously (or currently) installed the DosDude patches?