If you will going to use the NVMe blade as a main disk, you can only use HFS+ up to High Sierra, Mojave requires APFS.Hi. sorry for the late response I've been busy as hell. Well, I use my computer mainly for music production, eventually some video editing but nothing too fancy, But music Production heavy loads!!!!!, a lot of Samplers and Virtual Instruments, I've been trying to find also what would be the best option for the NVME if APFS or HFS, THanks!!! It's a Mac Pro 5,1 2010, 12 cores 2.66 GHz
Btw, NVMe is only supported by the following macOS releases and with these conditions:
El Capitan - only Apple SSPOLARIS blades and only after 10.11.4.
Sierra - only Apple SSPOLARIS blades and M.2 blades that support 4096 bytes/sector (not common / usually datacenter blades)
High Sierra - general NVMe support, both 512 bytes/sector and 4096 bytes/sector are supported
Mojave - general NVMe support, both 512 bytes/sector and 4096 bytes/sector are supported
Edit:
Corrected a typo.
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