I can understand turning to guides and online help when you get stuck and it would be frustrating otherwise, but some aspects of the game should be left alone.
I think Bethesda have done a good job with actually making alchemy interesting as there is a sense of mystery and learning as you progress with this skill. An attempt has been made to simulate some kind of realism (as far as that's possible in a computer game). New potions can be acquired by experimentation and by buying or finding recipes.
I think people really should be careful not to take the fun out the game by using exploits too much. I've heard people mention bows that kill dragons with one shot. Where's the fun in that? Everything you meet is easily dispatched and treasure holds no value.
I agree with what you say about guides and gameplay, but on the flip side I have some rambles.
One of the main the reason I buy guides, is to get something more tangible than what's included in these sparse retail boxes now days; and ONLY for the games I really enjoy, so Skyrim was a no brainer; I also bought the 4 disc Soundtrack.
I look at the guide as great tangible reference book to just have around, especially for a title that I know I'm going to replay more than once, or if and when I'm trying to recall something.
I always go as far as I can on my own before referencing my guides -- given I've even bought one. With Dragon Age: Origins as example, I played it on nightmare-difficulty up until I knew that the Arch dragon was my next main plot-point ( so a game ender ), then at that time I dove into my guide to cross reference what I have and have not completed.
I've completely way more games than I've bought guides, but for a game like Skyrim, I view it as plus.
And to put the kill a dragon with one shot into "context"; early on, that would be massive cheese, but I wouldn't mind a weapon like that if I earned it through countless hours of play and only through great difficulty, so that it's a reward. But I wouldn't want an item like that to be effective on an end boss. I'd only want it to be effective on a certain level at beast -- so lower level dragons if they exist in Skyrim? I'm not far enough to know if there are different levels of dragons outside of fire and ice as an example.
Anyways, way more to the above. But even with all my rambling, I do agree with your points. I never had guides or the option uber-death weapons on the games I played back when I was younger, but on the other hand I had way more time to play games and figure them all out on my own.