That’s exactly my issue. It becomes unbearable when I work in Cubasis and plug midi keyboard (irig keyboard I/O) that charges the iPad. Without charging it becomes much better but the issue still persists.My ipp 12,9” 2nd gen becomes unresponsive from time to time and especially when charging it. However, when it is unresponsive it reacts to the pencil as normal but not reacts to my fingers at all.