The thread where you asked to repurpose your eGPU enclosure but started the question on U.2 SSD.
It turns out a PCIe enclosure housing NVMe SSD may make a lot of sense with the Mac Studio now, as we discuss the reliability of the bus-powered ones.
Got it. Yes, as the new thread linked in post #78 says I'm going with M.2. I think that U.2 involves unnecessary complications including availability of the SSDs.
I think that there are three issues with most of the enclosures that are being used. You've identified one, the fact that most of them are bus-powered. As you suggest, this may be why people frequently report disconnects.
The second arises from the fact that most of these DIY enclosures are very small and quickly get very hot. I think that they're an invitation to throttling. That is less of an issue with a PCIe slot in a tower computer, and I don't expect any heat issue with the Asus GPU enclosure.
Also, most if not all of the enclosures available on Amazon, which are what most people are buying, will only take one SSD.