Civ V launched from Steam creates a black screen for a few seconds, the sound starts, then a low-res flicker, and back to the steam screen. Won't launch at all. Mid 2010 MBP 15" 2.66 330M 8GB 10.6.5.
Many other reports floating around - avoid this turkey.
10.6.5 has issues I believe. 10.6.4 here and it work perfectly, never crashed in the 4 games I played, some online.
email Aspyr, they reply quickly.