Geez, I have just started using my iPad with a lamp light needed now as nightfall approaches. I was starting to get a headache and the lamp on my left side was visible to mostly my left eye. The lamp is now totally behind me and where do I send my payment to you instead of getting my vision checked by a doctor.
This is how my bedroom looks like at 4:50 PM
http://imgur.com/a/j0nW6
I am capable of using the iPAD in the bed or in a table I am going to install next to the wardrobe without any eye strain. Bias lighting is the way to go. I can also use this LCD from the image, since the photos make the light from the lampshade appear to be much brighter than it really is. The trick is to light the entire room without at any moment you been able to look directly into the lamp, which must be hidden from your sight. You also need to calculate how much light is needed for each room,
click here for more details. In the Imgur link there's only one LED with 803 lumens and the room has 10.64 m². I prefer warm-white (3000K) despite what that article says. Warm could be better in the evening so as not to upset your sleep pattern. Cool light would be telling your brain that it is daytime and time to work which is not what you need.
If we're talking about extended nighttime use, warm color temperatures really are healthier than cool ones. Warm light (not just LEDs, but of any lighting device) is going to have a lower percentage of blue and green wavelengths. Blue and green wavelengths severely block melatonin production at night, leading to many of the maladies associated with shift work syndrome.
There are other things that I recommend to reduce eye strain, such as visiting your doctor to get new prescription for your eyeglasses - after a few years the anti-reflective coating is no longer there. Get a new anti-reflective treatment from a reputable brand. I have myopia, and doing this after ditching my old glasses improved my experience while spending some time using the iPAD. I don't recommend a coating specially developed to block blue light because you can't turn this off (unless you don't use the glasses) and it appears the screens look like they have Night Shift on 24/7.
Using good (also from a known brand) sunglasses that block glare during the day... killing all the lights inside the bedroom when you are going to sleep (it has to be in total darkness...) will help, too. And about reducing brightness, you need to do this not only in your iPAD, it has to be done in all eletronic devices.
When the Airpods were released some people complained about the same symptoms that are mentioned here about this new iPAD:
https://forums.macrumors.com/threads/airpods-and-headache-ear-pain.2022765/page-5#post-24518901
It turns out they are more sensitive to Bluetooth, and the above link says that if your health isn't ideal then you may be less prone to accept how the Airpods affect YOU. In other words, some feel this way because they have been subjected to "abuse" and aren't equipped to deal with this new technology as others have.
Not many people complain about the Airpods, and I haven't felt (after all this time) the side effects mentioned by these few. I suspect this is also the case for the iPAD Pro 10.5. There are many ways in which we can get eye strain, and testing effectively if the new screen from the iPAD is the sole culprit won't be possible if we don't pay attention to everything I mentioned before.
I suspect even in ideal conditions we will need to adapt ourselves to how this new screen works. This isn't the first time someone complains about 120Hz
http://www.overclock.net/t/1528094/120hz-eye-strain