yes you can do it easily, update to Ventura 13.1... (I have also iMac 21.5 2011 with quadro k1000m)
1. however if you use OCLP 0.53 surely the wifi module will not work so you should use a compatible usb key and a small program (Wireless.USB.Big.Sur.Adapter-V17), otherwise you have to use OCLP 0.54 nightly, the wifi will work but you will surely a graphic bug in the menu bar, some icons on the right would not be displayed including control center, widget, date, time, wifi, bluetooh but everything would work (I am attaching what happens to me on iMac 12.1);
2. for me with k1000m graphics card (I think it's a general problem of Nvidia quadro kxxxx cards unless future corrections with OCLP) the integrated audio output no longer works, the built-in speakers to understand (lack of driver for integrated output, all due , I think, to the type of graphics card, to some of its components) but the headphone output would work so with connected external speakers you will have audio... in general I'm quite satisfied except, for now, for this small bug of the icons in the menu bar.. .